COX-2 targeting indomethacin conjugated fluorescent probe
- Authors
- Kim, Hyeong Seok; Park, Taegun; Ren, Wen Xiu; Lim, Ja-Yun; Won, Miae; Heo, June Seok; Lee, Seung Gwan; Kim, Jong Seung
- Issue Date
- 3월-2018
- Publisher
- ELSEVIER SCI LTD
- Keywords
- COX-2 enzyme; Indomethacin; Fluorescent imaging; Bioimaging; Cancer detection
- Citation
- DYES AND PIGMENTS, v.150, pp.261 - 266
- Indexed
- SCIE
SCOPUS
- Journal Title
- DYES AND PIGMENTS
- Volume
- 150
- Start Page
- 261
- End Page
- 266
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/76843
- DOI
- 10.1016/j.dyepig.2017.11.053
- ISSN
- 0143-7208
- Abstract
- The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.
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- Appears in
Collections - College of Health Sciences > School of Health and Environmental Science > 1. Journal Articles
- College of Science > Department of Chemistry > 1. Journal Articles
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