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Valerian/Cascade mixture promotes sleep by increasing non-rapid eye movement (NREM) in rodent model

Authors
Choi, Hyeon-SonHong, Ki-BaeHan, Sung HeeSuh, Hyung Joo
Issue Date
3월-2018
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Keywords
Sleep-promotion; Valerian; Cascade; Non-rapid eye movement; GABA receptor
Citation
BIOMEDICINE & PHARMACOTHERAPY, v.99, pp.913 - 920
Indexed
SCIE
SCOPUS
Journal Title
BIOMEDICINE & PHARMACOTHERAPY
Volume
99
Start Page
913
End Page
920
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/77215
DOI
10.1016/j.biopha.2018.01.159
ISSN
0753-3322
Abstract
The aim of this study was to investigate the beneficial effect of Valerian/Cascade mixture on sleeping in mammal models. In pentobarbital-induced sleep model, Valerian, Cascade, and Valerian/Cascade mixture significantly reduced the latency time for sleeping, and total sleeping time effectively increased in these sample groups compared with the control. Valerian/Cascade mixture increased sleep duration by 37%. The mixture significantly increased the non-rapid eye movement (NREM) sleep time by 53% compared with the control, while REM sleeping time was decreased by 33% with Valerian/Cascade mixture, in Electroencephalography (EEG) analysis, resulting in the increase of total sleep time and the decrease of awakening. This sleep-promoting effect was obvious in caffeine-induced awakening model; Valerian, Cascade, and the mixture significantly enhanced NREM and total sleep time, which were reduced by caffeine. Caffeine-induced increase of awakening was effectively deceased to the normal level by these three samples. In particular, delta wave responsible for deep sleep in NREM was greatly increased by the mixture in both normal and caffeine-induced awake models. This sleep-promoting effect of Valerian/Cascade mixture was shown to be due to the upregulation of gamma-aminobutyric acid A receptor (GABAAR). Valerian/Cascade mixture showed 91% binding capacity to GABAA-BZD receptor. Two compounds, Valerenic acid and Xanthohumol, were shown to significantly contribute to the binding activity of Valerian/Cascade mixture on the GABA receptor.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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