Conversion of glioma cells to glioma stem-like cells by angiocrine factors
DC Field | Value | Language |
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dc.contributor.author | Kim, Jun-Kyum | - |
dc.contributor.author | Jeon, Hye-Min | - |
dc.contributor.author | Jeon, Hee-Young | - |
dc.contributor.author | Oh, Se-Yeong | - |
dc.contributor.author | Kim, Eun-Jung | - |
dc.contributor.author | Jin, Xiong | - |
dc.contributor.author | Kim, Se-Hoon | - |
dc.contributor.author | Kim, Sung-Hak | - |
dc.contributor.author | Jin, Xun | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.date.accessioned | 2021-09-02T14:54:50Z | - |
dc.date.available | 2021-09-02T14:54:50Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-02-19 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77333 | - |
dc.description.abstract | Glioma stem-like cells (GSCs) contribute to tumor initiation, progression, and therapeutic resistance, but their cellular origin remains largely unknown. Here, using a stem/progenitor cell-fate tracking reporter system in which eGFP is expressed by promoter of OCT4 that is activated in stem/progenitor cells, we demonstrate that eGFP-negative glioma cells (GCs) became eGFP-positive-GCs in both in vitro cultures and in vivo xenografts. These eGFP-positive-GCs exhibited GSC features and primarily localized to the perivascular region in tumor xenografts, similar to the existence of OCT4-expressing GCs in the perivascular region of human glioblastoma specimens. Angiocrine factors, including nitric oxide (NO), converted eGFP-negative-GCs into eGFP-positive-GCs. Mechanistically, NO signaling conferred GSC features to GCs by increasing OCT4 and NOTCH signaling via ID4. NO signaling blockade and a suicide gene induction prevented tumorigenicity with a decrease in eGFP-positive-GCs in the perivascular region. Taken together, our results reveal the molecular mechanism underlying GSCs generation by cancer cell dedifferentiation. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | ACUTE MYELOID-LEUKEMIA | - |
dc.subject | SELF-RENEWAL | - |
dc.subject | EXPRESSION | - |
dc.subject | CROSSTALK | - |
dc.title | Conversion of glioma cells to glioma stem-like cells by angiocrine factors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyunggee | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.02.076 | - |
dc.identifier.scopusid | 2-s2.0-85013762412 | - |
dc.identifier.wosid | 000426336400001 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.496, no.4, pp.1013 - 1018 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 496 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1013 | - |
dc.citation.endPage | 1018 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | ACUTE MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CROSSTALK | - |
dc.subject.keywordAuthor | Angiocrine factors | - |
dc.subject.keywordAuthor | Glioma cells | - |
dc.subject.keywordAuthor | Glioma stem-like cells | - |
dc.subject.keywordAuthor | ID4 | - |
dc.subject.keywordAuthor | OCT4 | - |
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