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Small-animal PET imaging analysis with [F-18]FHBG in a mouse model of HSV1-tk gene expression in melanoma
- Authors
- Lee, Onseok; Kim, Jaeyoung; Oh, Chilhwan
- Issue Date
- 2월-2018
- Publisher
- WILEY
- Keywords
- [F-18]FDG; [F-18]FHBG; HSV1-tk; lentiviral vector; melanoma; small-animal PET; CT
- Citation
- EXPERIMENTAL DERMATOLOGY, v.27, no.2, pp.199 - 201
- Indexed
- SCIE
SCOPUS
- Journal Title
- EXPERIMENTAL DERMATOLOGY
- Volume
- 27
- Number
- 2
- Start Page
- 199
- End Page
- 201
- ISSN
- 0906-6705
- Abstract
- The purpose of this study was to establish a small-animal model for molecular imaging and to acquire basic data on assessing the efficacy of candidate melanoma drugs using small-animal PET imaging analysis with [F-18]FHBG for herpes simplex virus 1-thymidine kinase (HSV1-tk) gene expression in a melanoma mouse model. The B16 melanoma cell line was transduced with a recombinant lentiviral vector containing the HSV1-tk gene and inoculated into the back skin of C57BL/6J mice. [F-18]FHBG PET imaging showed better contrast for HSV1-tk(+) melanomas compared to brain, heart, gall bladder, intestine and kidney than did [F-18]FDG PET imaging.
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