TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Heonjong | - |
dc.contributor.author | Cho, Jae-Won | - |
dc.contributor.author | Lee, Sangyoung | - |
dc.contributor.author | Yun, Ayoung | - |
dc.contributor.author | Kim, Hyojin | - |
dc.contributor.author | Bae, Dasom | - |
dc.contributor.author | Yang, Sunmo | - |
dc.contributor.author | Kim, Chan Yeong | - |
dc.contributor.author | Lee, Muyoung | - |
dc.contributor.author | Kim, Eunbeen | - |
dc.contributor.author | Lee, Sungho | - |
dc.contributor.author | Kang, Byunghee | - |
dc.contributor.author | Jeong, Dabin | - |
dc.contributor.author | Kim, Yaeji | - |
dc.contributor.author | Jeon, Hyeon-Nae | - |
dc.contributor.author | Jung, Haein | - |
dc.contributor.author | Nam, Sunhwee | - |
dc.contributor.author | Chung, Michael | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Lee, Insuk | - |
dc.date.accessioned | 2021-09-02T16:16:36Z | - |
dc.date.available | 2021-09-02T16:16:36Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-01-04 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/78007 | - |
dc.description.abstract | Transcription factors (TFs) are major trans-acting factors in transcriptional regulation. Therefore, elucidating TF-target interactions is a key step toward understanding the regulatory circuitry underlying complex traits such as human diseases. We previously published a reference TF-target interaction database for humans-TRRUST (Transcriptional Regulatory Relationships Unraveled by Sentencebased Text mining)-which was constructed using sentence-based text mining, followed by manual curation. Here, we present TRRUST v2 (www. grnpedia. org/trrust) with a significant improvement from the previous version, including a significantly increased size of the database consisting of 8444 regulatory interactions for 800 TFs in humans. More importantly, TRRUST v2 also contains a database for TF-target interactions in mice, including 6552 TF-target interactions for 828 mouse TFs. TRRUST v2 is also substantially more comprehensive and less biased than other TF-target interaction databases. We also improved the web interface, which now enables prioritization of key TFs for a physiological condition depicted by a set of user-input transcriptional responsive genes. With the significant expansion in the database size and inclusion of the new web tool for TF prioritization, we believe that TRRUST v2 will be a versatile database for the study of the transcriptional regulation involved in human diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | GENE | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | PROLIFERATION | - |
dc.title | TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.identifier.doi | 10.1093/nar/gkx1013 | - |
dc.identifier.scopusid | 2-s2.0-85040866401 | - |
dc.identifier.wosid | 000419550700058 | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.46, no.D1, pp.D380 - D386 | - |
dc.relation.isPartOf | NUCLEIC ACIDS RESEARCH | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 46 | - |
dc.citation.number | D1 | - |
dc.citation.startPage | D380 | - |
dc.citation.endPage | D386 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.