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TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions

Authors
Han, HeonjongCho, Jae-WonLee, SangyoungYun, AyoungKim, HyojinBae, DasomYang, SunmoKim, Chan YeongLee, MuyoungKim, EunbeenLee, SunghoKang, ByungheeJeong, DabinKim, YaejiJeon, Hyeon-NaeJung, HaeinNam, SunhweeChung, MichaelKim, Jong-HoonLee, Insuk
Issue Date
4-1월-2018
Publisher
OXFORD UNIV PRESS
Citation
NUCLEIC ACIDS RESEARCH, v.46, no.D1, pp.D380 - D386
Indexed
SCIE
SCOPUS
Journal Title
NUCLEIC ACIDS RESEARCH
Volume
46
Number
D1
Start Page
D380
End Page
D386
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/78007
DOI
10.1093/nar/gkx1013
ISSN
0305-1048
Abstract
Transcription factors (TFs) are major trans-acting factors in transcriptional regulation. Therefore, elucidating TF-target interactions is a key step toward understanding the regulatory circuitry underlying complex traits such as human diseases. We previously published a reference TF-target interaction database for humans-TRRUST (Transcriptional Regulatory Relationships Unraveled by Sentencebased Text mining)-which was constructed using sentence-based text mining, followed by manual curation. Here, we present TRRUST v2 (www. grnpedia. org/trrust) with a significant improvement from the previous version, including a significantly increased size of the database consisting of 8444 regulatory interactions for 800 TFs in humans. More importantly, TRRUST v2 also contains a database for TF-target interactions in mice, including 6552 TF-target interactions for 828 mouse TFs. TRRUST v2 is also substantially more comprehensive and less biased than other TF-target interaction databases. We also improved the web interface, which now enables prioritization of key TFs for a physiological condition depicted by a set of user-input transcriptional responsive genes. With the significant expansion in the database size and inclusion of the new web tool for TF prioritization, we believe that TRRUST v2 will be a versatile database for the study of the transcriptional regulation involved in human diseases.
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