Development of Prediction Equation of Diffusing Capacity of Lung for Koreans

Abstract

Background: The diffusing capacity of the lung is influenced by multiple factors such as age, sex, height, weight, ethnicity and smoking status. Although a prediction equation for the diffusing capacity of Korea was proposed in the mid-1980s, this equation is not used currently. The aim of this study was to develop a new prediction equation for the diffusing capacity for Koreans. Methods: Using the data of the Korean National Health and Nutrition Examination Survey, a total of 140 nonsmokers with normal chest X-rays were enrolled in this study. Results: Using linear regression analysis, a new predicting equation for diffusing capacity was developed. For men, the following new equations were developed: carbon monoxide diffusing capacity (DLco)=-10.4433-0.1434xage (year)+0.2482xheights (cm); DLco/alveolar volume (VA)=6.01507-0.02374xage (year)-0.00233xheights (cm). For women the prediction equations were described as followed: DLco=-12.8895-0.0532xage (year)+ 0.2145xheights (cm) and DLco/VA=7.69516-0.02219xage (year)-0.01377xheights (cm). All equations were internally validated by k-fold cross validation method. Conclusion: In this study, we developed new prediction equations for the diffusing capacity of the lungs of Koreans. A further study is needed to validate the new predicting equation for diffusing capacity.