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Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system
- Issue Date
- 1월-2018
- Publisher
- ELSEVIER
- Citation
- STEM CELL RESEARCH, v.26, pp.72 - 75
- Indexed
- SCIE
SCOPUS
- Journal Title
- STEM CELL RESEARCH
- Volume
- 26
- Start Page
- 72
- End Page
- 75
- ISSN
- 1873-5061
- Abstract
- Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening and toxicity testing. Here, we generated a PXR-mCherry reporter human induced pluripotent stem cell (hiPSC) line using the CRISPR/Cas9 system. PXR-mCherry hiPSCs were pluripotent and had differentiation potential and a normal karyotype. This cell line is an important tool for identifying factors that increase PXR-mediated drug metabolism and hepatocyte proliferation. (C) 2017 The Authors. Published by Elsevier B.V.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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