Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Antiviral activity of ginsenoside Rg3 isomers against gammaherpesvirus through inhibition of p38-and JNK-associated pathways

Authors
Kang, SoowonSong, Moon JungMin, Hyeyoung
Issue Date
1월-2018
Publisher
ELSEVIER SCIENCE BV
Keywords
Panax ginseng; Ginsenoside Rg3; Antiviral activity; Gammaherpesvirus; MAP Kinases
Citation
JOURNAL OF FUNCTIONAL FOODS, v.40, pp.219 - 228
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF FUNCTIONAL FOODS
Volume
40
Start Page
219
End Page
228
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/78083
DOI
10.1016/j.jff.2017.11.011
ISSN
1756-4646
Abstract
Natural compounds from functional foods targeting viruses are considered to have important role for regulating virus-related diseases. Ginsenoside Rg3 is one of the active pharmaceutical components found in Panax ginseng C.A. Meyer which is widely used as a functional food in East Asia. In our present study, we have characterized the antiviral activities of the ginsenoside Rg3 isomers, 20(R)- and 20(S)-ginsenoside Rg3, against murine gammaherpesvirus 68 (MHV-68), a mouse model of human gammaherpesvirus which can cause various malignancies including cancer. We found that both 20(R)- and 20(S)-ginsenoside Rg3 inhibited lytic replication and viral proliferation of MHV-68, although 20(S)-ginsenoside Rg3 was more effective than 20(R)-ginsenoside Rg3. Furthermore, ginsenoside Rg3 isomers efficiently repressed chemically-induced lytic replication of human gammaherpesviruses in EBV-positive BC-3 and KSHV-positive Raji cell lines. Finally, our data showed that ginsenoside Rg3 isomers suppressed the p38 and/or the JNK-associated MAPK signaling pathways, thereby inhibiting viral replication.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Song, Moon Jung photo

Song, Moon Jung
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE