Emerging Roles of TWIK-1 Heterodimerization in the Brain
- Authors
- Cho, Chang-Hoon; Hwang, Eun Mi; Park, Jae-Yong
- Issue Date
- 1월-2018
- Publisher
- MDPI
- Keywords
- TWIK-1; K2P; astrocyte; brain; heterodimerization
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 19
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/78473
- DOI
- 10.3390/ijms19010051
- ISSN
- 1661-6596
- Abstract
- Two-pore domain K+ (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIKtandem of pore domains in a weak inward rectifying K+ channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.