Olfactory dysfunctions in drug-naive Parkinson's disease with mild cognitive impairment
DC Field | Value | Language |
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dc.contributor.author | Park, Jin-Woo | - |
dc.contributor.author | Kwon, Do-Young | - |
dc.contributor.author | Choi, Ji Ho | - |
dc.contributor.author | Park, Moon-Ho | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.date.accessioned | 2021-09-02T17:06:54Z | - |
dc.date.available | 2021-09-02T17:06:54Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/78479 | - |
dc.description.abstract | Background: Evaluation of olfactory function is valuable for the detection of pre-motor state of Parkinson's disease (PD). PD patients have an increased risk of associated dementia and one-third of PP patients have mild cognitive impairment (MCI) at the time of diagnosis. However, the characteristics of olfactory dysfunction in PD-MCI patients are unclear. This study examined the relationship between olfactory dysfunction and cognitive function in drug-naive PD at the time of diagnosis with the patterns of olfactory function in PD-MCI patients using the Korean version of the Sniffin' stick test II (KVSS II). Methods: A total of 66 drug-naive PD patients were enrolled. A neuropsychiatric assessment battery and KVSS II were performed. For the statistical analyses, univariate, multivariable linear regression and Student's t-test were used to determine the relationship between the variables and olfactory function. Results: Olfactory dysfunction was more prevalent in the PD-MCI group than in the PD-normal cognition (PD-CN) group. Each domains of odor threshold, discrimination, identification and total olfactory score were more impaired in the PD-MCI group than the PD-CN group. Whether cognitive impairment was single or multiple domain was not affected. Conclusion: PD-MCI is more likely to be associated with severe olfactory impairment than PD-CN. There may be more extensive neurodegenerative processes affecting olfaction in PD-MCI patients. With further investigation and validation using neuropathological data, an objective olfactory function test could be used as a tool to evaluate disease progression. Further studies with prospective design investigating the prognostic value of olfactory dysfunction in PD-MCI patients are essential. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | DIAGNOSTIC-CRITERIA | - |
dc.subject | KOREAN VERSION | - |
dc.subject | DEMENTIA | - |
dc.title | Olfactory dysfunctions in drug-naive Parkinson's disease with mild cognitive impairment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Do-Young | - |
dc.contributor.affiliatedAuthor | Park, Moon-Ho | - |
dc.contributor.affiliatedAuthor | Yoon, Ho-Kyoung | - |
dc.identifier.doi | 10.1016/j.parkreldis.2017.11.334 | - |
dc.identifier.scopusid | 2-s2.0-85040111617 | - |
dc.identifier.wosid | 000419811800013 | - |
dc.identifier.bibliographicCitation | PARKINSONISM & RELATED DISORDERS, v.46, pp.69 - 73 | - |
dc.relation.isPartOf | PARKINSONISM & RELATED DISORDERS | - |
dc.citation.title | PARKINSONISM & RELATED DISORDERS | - |
dc.citation.volume | 46 | - |
dc.citation.startPage | 69 | - |
dc.citation.endPage | 73 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | DIAGNOSTIC-CRITERIA | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordAuthor | Mild cognitive impairment | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Olfactory dysfunction | - |
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