Olfactory dysfunctions in drug-naive Parkinson's disease with mild cognitive impairment
- Authors
- Park, Jin-Woo; Kwon, Do-Young; Choi, Ji Ho; Park, Moon-Ho; Yoon, Ho-Kyoung
- Issue Date
- 1월-2018
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Mild cognitive impairment; Parkinson' s disease; Olfactory dysfunction
- Citation
- PARKINSONISM & RELATED DISORDERS, v.46, pp.69 - 73
- Indexed
- SCIE
SCOPUS
- Journal Title
- PARKINSONISM & RELATED DISORDERS
- Volume
- 46
- Start Page
- 69
- End Page
- 73
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/78479
- DOI
- 10.1016/j.parkreldis.2017.11.334
- ISSN
- 1353-8020
- Abstract
- Background: Evaluation of olfactory function is valuable for the detection of pre-motor state of Parkinson's disease (PD). PD patients have an increased risk of associated dementia and one-third of PP patients have mild cognitive impairment (MCI) at the time of diagnosis. However, the characteristics of olfactory dysfunction in PD-MCI patients are unclear. This study examined the relationship between olfactory dysfunction and cognitive function in drug-naive PD at the time of diagnosis with the patterns of olfactory function in PD-MCI patients using the Korean version of the Sniffin' stick test II (KVSS II). Methods: A total of 66 drug-naive PD patients were enrolled. A neuropsychiatric assessment battery and KVSS II were performed. For the statistical analyses, univariate, multivariable linear regression and Student's t-test were used to determine the relationship between the variables and olfactory function. Results: Olfactory dysfunction was more prevalent in the PD-MCI group than in the PD-normal cognition (PD-CN) group. Each domains of odor threshold, discrimination, identification and total olfactory score were more impaired in the PD-MCI group than the PD-CN group. Whether cognitive impairment was single or multiple domain was not affected. Conclusion: PD-MCI is more likely to be associated with severe olfactory impairment than PD-CN. There may be more extensive neurodegenerative processes affecting olfaction in PD-MCI patients. With further investigation and validation using neuropathological data, an objective olfactory function test could be used as a tool to evaluate disease progression. Further studies with prospective design investigating the prognostic value of olfactory dysfunction in PD-MCI patients are essential. (C) 2017 Elsevier Ltd. All rights reserved.
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