Haplotype Association of the &ITMAP2K5&IT Gene with Antipsychotics-Induced Symptoms of Restless Legs Syndrome among Patients with Schizophrenia
DC Field | Value | Language |
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dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Lee, Yu Jin | - |
dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Kim, Leen | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.date.accessioned | 2021-09-02T17:14:43Z | - |
dc.date.available | 2021-09-02T17:14:43Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/78537 | - |
dc.description.abstract | Objective Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of MAP2K5 are associated with antipsychotics-induced RLS in schizophrenia. Methods We assessed antipsychotics-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. Five single-nucleotide polymorphisms (SNPs) of MAP2K5 were genotyped. We investigated genetic and haplotypic associations of these five SNPs with the risk of antipsychotics-induced RLS symptoms. Results We divided the 190 subjects into 2 groups: 1) those with RLS symptoms (n-96) and 2) those without RLS symptoms (n=94). There were no significant intergroup differences in the distributions of the genotypes and alleles of the rs1026732, rs11635424, rs12593813, rs4489954, and rs3784709 SNPs. However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424rs12593813-rs4489954-rs3784709) haplotype was associated with RIS symptoms (permutation p=0.033). Conclusion These data su est that a haplotype of MAP2K5 polymorphisms confers increased susceptibility to antipsychotics-induced RLS symptoms in schizophrenic patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROPSYCHIATRIC ASSOC | - |
dc.subject | PERIODIC LIMB MOVEMENTS | - |
dc.subject | ATYPICAL ANTIPSYCHOTICS | - |
dc.subject | SYNDROME LOCUS | - |
dc.subject | RATING-SCALE | - |
dc.subject | RISK-FACTOR | - |
dc.subject | POLYMORPHISMS | - |
dc.subject | VARIANTS | - |
dc.subject | LINKAGE | - |
dc.subject | SLEEP | - |
dc.subject | POPULATION | - |
dc.title | Haplotype Association of the &ITMAP2K5&IT Gene with Antipsychotics-Induced Symptoms of Restless Legs Syndrome among Patients with Schizophrenia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Leen | - |
dc.contributor.affiliatedAuthor | Lee, Heon-Jeong | - |
dc.identifier.doi | 10.4306/pi.2018.15.1.84 | - |
dc.identifier.scopusid | 2-s2.0-85042595241 | - |
dc.identifier.wosid | 000423397400013 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, v.15, no.1, pp.84 - 89 | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.citation.title | PSYCHIATRY INVESTIGATION | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 84 | - |
dc.citation.endPage | 89 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002310979 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | PERIODIC LIMB MOVEMENTS | - |
dc.subject.keywordPlus | ATYPICAL ANTIPSYCHOTICS | - |
dc.subject.keywordPlus | SYNDROME LOCUS | - |
dc.subject.keywordPlus | RATING-SCALE | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | LINKAGE | - |
dc.subject.keywordPlus | SLEEP | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | Restless legs syndrome | - |
dc.subject.keywordAuthor | Antipsychotics | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.subject.keywordAuthor | MAP2K5 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Haplotype | - |
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