Haplotype Association of the &ITMAP2K5&IT Gene with Antipsychotics-Induced Symptoms of Restless Legs Syndrome among Patients with Schizophrenia
- Authors
- Kang, Seung-Gul; Lee, Yu Jin; Park, Young-Min; Kim, Leen; Lee, Heon-Jeong
- Issue Date
- 1월-2018
- Publisher
- KOREAN NEUROPSYCHIATRIC ASSOC
- Keywords
- Restless legs syndrome; Antipsychotics; Schizophrenia; MAP2K5; Polymorphism; Haplotype
- Citation
- PSYCHIATRY INVESTIGATION, v.15, no.1, pp.84 - 89
- Indexed
- SCIE
SSCI
SCOPUS
KCI
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 15
- Number
- 1
- Start Page
- 84
- End Page
- 89
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/78537
- DOI
- 10.4306/pi.2018.15.1.84
- ISSN
- 1738-3684
- Abstract
- Objective Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of MAP2K5 are associated with antipsychotics-induced RLS in schizophrenia. Methods We assessed antipsychotics-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. Five single-nucleotide polymorphisms (SNPs) of MAP2K5 were genotyped. We investigated genetic and haplotypic associations of these five SNPs with the risk of antipsychotics-induced RLS symptoms. Results We divided the 190 subjects into 2 groups: 1) those with RLS symptoms (n-96) and 2) those without RLS symptoms (n=94). There were no significant intergroup differences in the distributions of the genotypes and alleles of the rs1026732, rs11635424, rs12593813, rs4489954, and rs3784709 SNPs. However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424rs12593813-rs4489954-rs3784709) haplotype was associated with RIS symptoms (permutation p=0.033). Conclusion These data su est that a haplotype of MAP2K5 polymorphisms confers increased susceptibility to antipsychotics-induced RLS symptoms in schizophrenic patients.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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