Hypouricemic Effect of Ethanol Extract of Aster glehni Leaves in Potassium Oxonate-Induced Hyperuricemic RatsHypouricemic Effect of Ethanol Extract of Aster glehni Leaves in Potassium Oxonate-Induced Hyperuricemic Rats
- Other Titles
- Hypouricemic Effect of Ethanol Extract of Aster glehni Leaves in Potassium Oxonate-Induced Hyperuricemic Rats
- Authors
- 박지은; Hyo Seok Kang; Heui Jong Yu; Eun Hye Han; 박근태; Zia Yeom; 임영희
- Issue Date
- 2018
- Publisher
- 한국임상영양학회
- Keywords
- Aster glehni; Hyperuricemia; Xanthine oxidase; Serum uric acid
- Citation
- Clinical Nutrition Research, v.7, no.2, pp.126 - 135
- Indexed
- KCI
- Journal Title
- Clinical Nutrition Research
- Volume
- 7
- Number
- 2
- Start Page
- 126
- End Page
- 135
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/79793
- ISSN
- 2287-3732
- Abstract
- The prevalence of gout is increasing worldwide, and control of serum uric acid level has been regarded as one of the therapeutic methods for gout. Inhibition of xanthine oxidase (XO) activity which can oxidize hypoxanthine to uric acid has been commonly proposed to decrease serum uric acid level. The aim of this study was to demonstrate the hypouricemic effect of ethanol extract of Aster glehni leaves (EAG) by in vitro and in vivo study in potassium oxonate (PO)-induced hyperuricemic rats. EAG possessed 132.5 ± 6.8 mg QE/g of total flavonoid and showed antioxidant activity. EAG showed in vitro and in vivo inhibitory activity against XO and significantly decreased serum uric acid level in PO-induced hyperuricemic rats without liver toxicity. These results show that EAG significantly attenuates hyperuricemia by inhibiting XO activity, which resulted in the decrease of serum uric acid level. Therefore, EAG might possess a potential therapeutic ability for improving gout.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.