Chicoric acid mitigates impaired insulin sensitivity by improving mitochondrial function
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji-Sun | - |
dc.contributor.author | Lee, Hyunjung | - |
dc.contributor.author | Jung, Chang Hwa | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.contributor.author | Ha, Tae-Youl | - |
dc.contributor.author | Ahn, Jiyun | - |
dc.date.accessioned | 2021-09-02T21:10:57Z | - |
dc.date.available | 2021-09-02T21:10:57Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/80911 | - |
dc.description.abstract | Mitochondrial dysfunction is associated with insulin resistance. Although chicoric acid (CA) is known to have beneficial effects on insulin sensitivity, the involvement of mitochondrial function has not been elucidated yet. Here, we investigated the effect of CA on insulin resistance and mitochondrial dysfunction. In palmitate-induced insulin-resistant C2C12 myotubes, CA improved impaired glucose uptake and insulin signaling pathways, along with enhanced mitochondrial membrane potential and oxygen consumption. CA treatment in diet-induced obese mice ameliorated glucose tolerance and increased insulin sensitivity. CA treatment also recovered the dysregulated expression of glucose metabolism-related genes in the high-fat-fed mice. CA significantly increased the mitochondrial DNA content, citrate synthase, and ATP content, as well as the expression of genes related to mitochondrial biogenesis and oxidative phosphorylation in the liver and skeletal muscle in high-fat- fed obese mice. These findings suggested that CA attenuates insulin resistance and promotes insulin sensitivity by enhancing mitochondrial function. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | CICHORIUM-INTYBUS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | PREVENTS OBESITY | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | RESISTANCE | - |
dc.subject | MECHANISMS | - |
dc.subject | DYSFUNCTION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | INFLAMMATION | - |
dc.subject | REDUCTION | - |
dc.title | Chicoric acid mitigates impaired insulin sensitivity by improving mitochondrial function | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sung-Joon | - |
dc.identifier.doi | 10.1080/09168451.2018.1451742 | - |
dc.identifier.scopusid | 2-s2.0-85049565140 | - |
dc.identifier.wosid | 000436822900019 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.82, no.7, pp.1197 - 1206 | - |
dc.relation.isPartOf | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 82 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1197 | - |
dc.citation.endPage | 1206 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | CICHORIUM-INTYBUS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PREVENTS OBESITY | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordAuthor | Chicoric acid | - |
dc.subject.keywordAuthor | glucose uptake | - |
dc.subject.keywordAuthor | diet-induced obesity | - |
dc.subject.keywordAuthor | insulin resistance | - |
dc.subject.keywordAuthor | mitochondria | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.