Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Distinct Patterns of Rich Club Organization in Alzheimer's Disease and Subcortical Vascular Dementia: A White Matter Network Study

Authors
Lee, Wha JinHan, Cheol E.Aganj, ImanSeo, Sang WonSeong, Joon-Kyung
Issue Date
2018
Publisher
IOS PRESS
Keywords
Alzheimer' s disease; diffusion tensor imaging; diffusion tractography; subcortical vascular dementia
Citation
JOURNAL OF ALZHEIMERS DISEASE, v.63, no.3, pp.977 - 987
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
Volume
63
Number
3
Start Page
977
End Page
987
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/80969
DOI
10.3233/JAD-180027
ISSN
1387-2877
Abstract
Recent advances in neuroimaging technology have shown that rich club organization in human brain networks plays a crucial role in global communication and cognitive functionality. In this study, we investigated rich club organization within white matter structural brain networks in two common types of dementia, Alzheimer's disease (AD) and subcortical vascular dementia (SVaD). We recruited 30 AD patients ([C-11] Pittsburgh compound-B (PiB) PET positive), 39 SVaD patients (PiB negative), and 72 age-, gender-, and education-matched cognitively normal (CN) subjects. Rich club organization was significantly disrupted in both dementia patient groups, which exhibited higher rich club coefficients than the CN group. Rich club organization in the patient groups was primarily disrupted over the left frontal and left middle temporal areas when compared to the CN group. The number of rich club nodes was significantly reduced in the dementia groups, which was more severe in SVaD (p = 0.0107, permutation-based t-test). Although rich club organization was disrupted both in the patient groups, its disruption pattern is different between them. The rich-club connections normalized by degree-and strength preserved random networks were significantly increased in the dementia groups with SVaD more severely, and feeder connections were reduced more significantly than in AD. Furthermore, SVaD patients exhibited more sporadic disruption in white matter connectivity than AD patients, with local connections showing a more significant degree of deterioration. Combined with the distinct disruption in rich club nodes, these findings may imply a differing role for rich club organization in AD and SVaD, due to different pathological mechanisms.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Electronics and Information Engineering > 1. Journal Articles
Graduate School > Department of Artificial Intelligence > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE