Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study
DC Field | Value | Language |
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dc.contributor.author | Minn, Yang-Ki | - |
dc.contributor.author | Choi, Seong Hye | - |
dc.contributor.author | Suh, Young Ju | - |
dc.contributor.author | Jeong, Jee Hyang | - |
dc.contributor.author | Kim, Eun-Joo | - |
dc.contributor.author | Kim, Jong Hun | - |
dc.contributor.author | Park, Kyung Won | - |
dc.contributor.author | Park, Moon Ho | - |
dc.contributor.author | Youn, Young Chul | - |
dc.contributor.author | Yoon, Bora | - |
dc.contributor.author | Choi, Seok-Jin | - |
dc.contributor.author | Oh, Youn Kyung | - |
dc.contributor.author | Yoon, Soo Jin | - |
dc.date.accessioned | 2021-09-02T21:21:23Z | - |
dc.date.available | 2021-09-02T21:21:23Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81000 | - |
dc.description.abstract | Background: There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD). Objectives: We investigated whether PA is associated with progression of dementia and mortality in AD. Methods: In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations. Results: Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95% CI = -0.824 similar to-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656 similar to-0.639; p < 0.001) for the high PA group (>750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with >= 150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with <150 minutes per week for each of the PAs (hazard ratio 0.22, 95% CI = 0.05 similar to 0.88; p = 0.033). Conclusion: More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.subject | GERIATRIC DEPRESSION SCALE | - |
dc.subject | OLDER-ADULTS | - |
dc.subject | COGNITIVE FUNCTION | - |
dc.subject | NEUROPSYCHIATRIC INVENTORY | - |
dc.subject | VERSION | - |
dc.subject | EXERCISE | - |
dc.subject | RISK | - |
dc.subject | TOOL | - |
dc.subject | DIAGNOSIS | - |
dc.subject | SYMPTOMS | - |
dc.title | Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Moon Ho | - |
dc.identifier.doi | 10.3233/JAD-180333 | - |
dc.identifier.scopusid | 2-s2.0-85055140592 | - |
dc.identifier.wosid | 000448213400014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, v.66, no.1, pp.249 - 261 | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.title | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.volume | 66 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 249 | - |
dc.citation.endPage | 261 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | GERIATRIC DEPRESSION SCALE | - |
dc.subject.keywordPlus | OLDER-ADULTS | - |
dc.subject.keywordPlus | COGNITIVE FUNCTION | - |
dc.subject.keywordPlus | NEUROPSYCHIATRIC INVENTORY | - |
dc.subject.keywordPlus | VERSION | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | TOOL | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | dementia | - |
dc.subject.keywordAuthor | physical activity | - |
dc.subject.keywordAuthor | progression | - |
dc.subject.keywordAuthor | mortality | - |
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