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Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study

Authors
Minn, Yang-KiChoi, Seong HyeSuh, Young JuJeong, Jee HyangKim, Eun-JooKim, Jong HunPark, Kyung WonPark, Moon HoYoun, Young ChulYoon, BoraChoi, Seok-JinOh, Youn KyungYoon, Soo Jin
Issue Date
2018
Publisher
IOS PRESS
Keywords
Alzheimer' s disease; dementia; physical activity; progression; mortality
Citation
JOURNAL OF ALZHEIMERS DISEASE, v.66, no.1, pp.249 - 261
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
Volume
66
Number
1
Start Page
249
End Page
261
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81000
DOI
10.3233/JAD-180333
ISSN
1387-2877
Abstract
Background: There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD). Objectives: We investigated whether PA is associated with progression of dementia and mortality in AD. Methods: In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations. Results: Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95% CI = -0.824 similar to-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656 similar to-0.639; p < 0.001) for the high PA group (>750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with >= 150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with <150 minutes per week for each of the PAs (hazard ratio 0.22, 95% CI = 0.05 similar to 0.88; p = 0.033). Conclusion: More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD.
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