Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Kim, Jae Seon | - |
dc.contributor.author | Kim, Baek Hee | - |
dc.contributor.author | Bak, Young-Tae | - |
dc.date.accessioned | 2021-09-02T21:24:08Z | - |
dc.date.available | 2021-09-02T21:24:08Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0253-4886 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81022 | - |
dc.description.abstract | Backgrounds and Aims: Biliary intraepithelial neoplasia (BilIN) is a precursor of cholangiocarcinoma (CC) and it has been associated with several chronic inflammatory conditions. This study aimed to elucidate the prevalence of BilIN in CC and its clinicopathological significance. Methods: Medical records of 193 patients with histologically confirmed CC were analyzed. We reviewed the pathology findings of 48 patients who underwent curative surgery for CC. Results: Of the 48 patients analyzed, 34 and 14 patients had extrahepatic and intrahepatic CC respectively. BilIN was detected in 28 patients (58%) and showed a significantly higher prevalence in extrahepatic CC (75%) than in intrahepatic CC (21%; p < 0.001). In the subgroup of 34 patients with extrahepatic CC, 25 and 9 patients were BilIN positive and negative respectively. Poor differentiation and T3 stage were significantly more common in the BilIN-negative group than in the BilIN-positive group (p < 0.05). The expression of MUC5AC, p53, and loss of Smad4 showed no difference between BilIN-positive CC and in BilIN-negative CC, but the Ki-67 expression was significantly higher (p < 0.05). Conclusion: BilIN-positive CC showed less invasiveness than negative cases. The Ki-67 expression was significantly higher in BilIN-positive CC. (C) 2017 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject | BILE-DUCT | - |
dc.subject | INTEROBSERVER AGREEMENT | - |
dc.subject | EPITHELIAL LESIONS | - |
dc.subject | HEPATOLITHIASIS | - |
dc.subject | TRACT | - |
dc.subject | CRITERIA | - |
dc.subject | PROPOSAL | - |
dc.title | Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Jae Seon | - |
dc.contributor.affiliatedAuthor | Kim, Baek Hee | - |
dc.contributor.affiliatedAuthor | Bak, Young-Tae | - |
dc.identifier.doi | 10.1159/000475848 | - |
dc.identifier.scopusid | 2-s2.0-85018886949 | - |
dc.identifier.wosid | 000431541100004 | - |
dc.identifier.bibliographicCitation | DIGESTIVE SURGERY, v.35, no.2, pp.116 - 120 | - |
dc.relation.isPartOf | DIGESTIVE SURGERY | - |
dc.citation.title | DIGESTIVE SURGERY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 116 | - |
dc.citation.endPage | 120 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | BILE-DUCT | - |
dc.subject.keywordPlus | INTEROBSERVER AGREEMENT | - |
dc.subject.keywordPlus | EPITHELIAL LESIONS | - |
dc.subject.keywordPlus | HEPATOLITHIASIS | - |
dc.subject.keywordPlus | TRACT | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | PROPOSAL | - |
dc.subject.keywordAuthor | Biliary intraepithelial neoplasia | - |
dc.subject.keywordAuthor | Cholangiocarcinoma | - |
dc.subject.keywordAuthor | Ki-67 | - |
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