Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma
- Authors
- Kim, Hyo Jung; Kim, Jae Seon; Kim, Baek Hee; Bak, Young-Tae
- Issue Date
- 2018
- Publisher
- KARGER
- Keywords
- Biliary intraepithelial neoplasia; Cholangiocarcinoma; Ki-67
- Citation
- DIGESTIVE SURGERY, v.35, no.2, pp.116 - 120
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIGESTIVE SURGERY
- Volume
- 35
- Number
- 2
- Start Page
- 116
- End Page
- 120
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81022
- DOI
- 10.1159/000475848
- ISSN
- 0253-4886
- Abstract
- Backgrounds and Aims: Biliary intraepithelial neoplasia (BilIN) is a precursor of cholangiocarcinoma (CC) and it has been associated with several chronic inflammatory conditions. This study aimed to elucidate the prevalence of BilIN in CC and its clinicopathological significance. Methods: Medical records of 193 patients with histologically confirmed CC were analyzed. We reviewed the pathology findings of 48 patients who underwent curative surgery for CC. Results: Of the 48 patients analyzed, 34 and 14 patients had extrahepatic and intrahepatic CC respectively. BilIN was detected in 28 patients (58%) and showed a significantly higher prevalence in extrahepatic CC (75%) than in intrahepatic CC (21%; p < 0.001). In the subgroup of 34 patients with extrahepatic CC, 25 and 9 patients were BilIN positive and negative respectively. Poor differentiation and T3 stage were significantly more common in the BilIN-negative group than in the BilIN-positive group (p < 0.05). The expression of MUC5AC, p53, and loss of Smad4 showed no difference between BilIN-positive CC and in BilIN-negative CC, but the Ki-67 expression was significantly higher (p < 0.05). Conclusion: BilIN-positive CC showed less invasiveness than negative cases. The Ki-67 expression was significantly higher in BilIN-positive CC. (C) 2017 S. Karger AG, Basel
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