Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways
DC Field | Value | Language |
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dc.contributor.author | Seong, R. -K. | - |
dc.contributor.author | Kim, J. -A. | - |
dc.contributor.author | Shin, O. S. | - |
dc.date.accessioned | 2021-09-02T21:28:46Z | - |
dc.date.available | 2021-09-02T21:28:46Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0001-723X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81057 | - |
dc.description.abstract | Wogonin, a flavonoid isolated from Scutellaria baicalensis, has attracted increasing scientific attention in recent years because of its potent anti-tumor activity. Its role during viral infection has largely been unexplored. Wogonin treatment effectively suppressed both influenza A and B virus replication in Madin-Darby Canine Kidney (MDCK) cells and human lung epithelial (A549) cells. In contrast, wogonin treatment following influenza A virus infection led to up-regulation of interferon (IFN)-induced antiviral signaling. Additionally, influenza A virus infection in A549 cells induced 5' adenosine monophosphate- activated protein kinase (AMPK) phosphorylation and activation in a time-dependent manner and wogonin treatment led to the suppression of AMPK phosphorylation. Furthermore, the treatment with AMPK-specific inhibitor (compound C; CC) attenuated influenza A virus replication. These data suggest that wogonin possesses a potent anti-influenza activity mediated by regulation of AMPK activation, suggesting that wogonin has the potential to be developed as an anti-influenza drug. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AEPRESS SRO | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | CANCER-CELLS | - |
dc.subject | A VIRUS | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | IN-VIVO | - |
dc.subject | REPLICATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | RESISTANCE | - |
dc.subject | BAICALIN | - |
dc.title | Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, O. S. | - |
dc.identifier.doi | 10.4149/av_2018_109 | - |
dc.identifier.scopusid | 2-s2.0-85049248696 | - |
dc.identifier.wosid | 000437959400009 | - |
dc.identifier.bibliographicCitation | ACTA VIROLOGICA, v.62, no.1, pp.78 - 85 | - |
dc.relation.isPartOf | ACTA VIROLOGICA | - |
dc.citation.title | ACTA VIROLOGICA | - |
dc.citation.volume | 62 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 78 | - |
dc.citation.endPage | 85 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | A VIRUS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | BAICALIN | - |
dc.subject.keywordAuthor | wogonin | - |
dc.subject.keywordAuthor | influenza | - |
dc.subject.keywordAuthor | interferon | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | anti-viral signaling | - |
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