Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways
- Authors
- Seong, R. -K.; Kim, J. -A.; Shin, O. S.
- Issue Date
- 2018
- Publisher
- AEPRESS SRO
- Keywords
- wogonin; influenza; interferon; AMPK; anti-viral signaling
- Citation
- ACTA VIROLOGICA, v.62, no.1, pp.78 - 85
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA VIROLOGICA
- Volume
- 62
- Number
- 1
- Start Page
- 78
- End Page
- 85
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81057
- DOI
- 10.4149/av_2018_109
- ISSN
- 0001-723X
- Abstract
- Wogonin, a flavonoid isolated from Scutellaria baicalensis, has attracted increasing scientific attention in recent years because of its potent anti-tumor activity. Its role during viral infection has largely been unexplored. Wogonin treatment effectively suppressed both influenza A and B virus replication in Madin-Darby Canine Kidney (MDCK) cells and human lung epithelial (A549) cells. In contrast, wogonin treatment following influenza A virus infection led to up-regulation of interferon (IFN)-induced antiviral signaling. Additionally, influenza A virus infection in A549 cells induced 5' adenosine monophosphate- activated protein kinase (AMPK) phosphorylation and activation in a time-dependent manner and wogonin treatment led to the suppression of AMPK phosphorylation. Furthermore, the treatment with AMPK-specific inhibitor (compound C; CC) attenuated influenza A virus replication. These data suggest that wogonin possesses a potent anti-influenza activity mediated by regulation of AMPK activation, suggesting that wogonin has the potential to be developed as an anti-influenza drug.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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