Early red blood cell abnormalities as a clinical variable in sepsis diagnosis
- Authors
- Ko, Eunji; Youn, Jung Min; Park, Hyung Sun; Song, Myeongjin; Koh, Kyung Hee; Lim, Choon Hak
- Issue Date
- 2018
- Publisher
- IOS PRESS
- Keywords
- Red blood cell aggregation; red blood cell deformability; sepsis; sepsis-related organ failure assessment
- Citation
- CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, v.70, no.3, pp.355 - 363
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
- Volume
- 70
- Number
- 3
- Start Page
- 355
- End Page
- 363
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81075
- DOI
- 10.3233/CH-180430
- ISSN
- 1386-0291
- Abstract
- BACKGROUND: Sepsis is a medical emergency during which early detection is closely associated with mortality. In sepsis, red blood cell (RBC) abnormalities have been reported. However, it is not known how early RBC abnormalities are expressed compared with various clinical manifestations used in sepsis-related organ failure assessment (SOFA). OBJECTIVE: Therefore, using a lipopolysaccharide (LPS)-induced sepsis model we investigated the clinical significance of RBC abnormalities as an early indicator in the detection of septic injury compared with clinical variables. METHODS: Sprague-Dawley rats received LPS (20 mg/kg) intraperitoneally. Aggregation indices (AIs) and aggregation half-time (T1/2), and elongation indices (EImax) were measured. Clinical data-related SOFA and lactate were measured at 2 h, 4 h, 8 h and 12 h after LPS injection. RESULTS: AIs increased at 4 h, and T1/2 decreased at 2 h after LPS injection. Platelet counts decreased at 4 h, and lactate increased at 2 h after LPS injection. AIs showed strong correlations with T1/2 and platelets, EI(max )increased at 2 h after LPS injection, while EI(max )had a positive correlation with lactate. CONCLUSIONS: RBC aggregation appears to be an early indicator of clinical deterioration in sepsis and may represent a diagnostic indicator in sepsis.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.