Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Observational Study of Clinical and Functional Progression Based on Initial Brain MRI Characteristics in Patients with Alzheimer's Disease

Authors
Choi, HojinYang, YoungSoonHan, Hyun JeongJeong, Jee HyangPark, Mee YoungKim, Yong BumJo, Kwang DeogChoi, Jin-YongKang, Kyung-HunKang, HeeyoungKwon, Do-YoungYoo, Bong-GooLee, Hyun JinShin, Byoung-SooJeon, Sung-ManKwon, Oh DaeKim, Jin-SukLee, Soo-JooKim, YoungsooPark, Tai-HwanKim, Young JinYang, Hui-JunPark, Hyun-YoungShin, Hae-EunLee, Jung SeokJung, Yo HanLee, Ae YoungShin, Dong-IckShin, Kyong JinPark, Kee Hyung
Issue Date
2018
Publisher
IOS PRESS
Keywords
Atrophy; brain imaging; cognitive function; hippocampus; white matter hyperintensities
Citation
JOURNAL OF ALZHEIMERS DISEASE, v.66, no.4, pp.1721 - 1730
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
Volume
66
Number
4
Start Page
1721
End Page
1730
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81078
DOI
10.3233/JAD-180565
ISSN
1387-2877
Abstract
Background: Magnetic resonance imaging (MRI) is a useful tool to predict the diagnosis and progression of Alzheimer's disease (AD), especially for primary physicians. However, the correlation between baseline MRI findings and AD progression has not been fully established. Objective: To investigate the correlation between hippocampal atrophy (HA) and white matter hyperintensities (WMH) on initial brain MRI images and the degree of cognitive decline and functional changes over 1 year. Methods: In this prospective, 12-month observational study, dementia outpatients were recruited from 29 centers across South Korea. Baseline assessments of HA and WMH on baseline brain MRI were derived as well as cognitive function, dementia severity, activities of daily living, and acetylcholinesterase inhibitor (AChEI) use. Follow-up assessments were conducted at 6 and 12 months. Results: Among 899 enrolled dementia patients, 748 were diagnosed with AD of whom 654 (87%) were taking AChEIs. Baseline WMH showed significant correlations with age, current alcohol consumption, and Clinical Dementia Rating score; baseline HA was correlated with age, family history, physical exercise, and the results of cognitive assessments. Among the AChEI group, changes in the Korean version of the Instrumental Activities of Daily Living (K-IADL) were correlated with the severity of HA on baseline brain MRI, but not with the baseline severity of WMH. In the no AChEI group, changes in K-IADL were correlated with the severity of WMH and HA at baseline. Conclusion: Baseline MRI findings could be a useful tool for predicting future clinical outcomes by primary physicians, especially in relation to patients' functional status.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kwon, Do Young photo

Kwon, Do Young
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE