Biosynthetic pathways of aminoglycosides and their engineering
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Je Won | - |
dc.contributor.author | Ban, Yeon Hee | - |
dc.contributor.author | Nam, Sang-Jip | - |
dc.contributor.author | Cha, Sun-Shin | - |
dc.contributor.author | Yoon, Yeo Joon | - |
dc.date.accessioned | 2021-09-02T22:45:04Z | - |
dc.date.available | 2021-09-02T22:45:04Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0958-1669 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81424 | - |
dc.description.abstract | Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics. As Nature's gift, some aminoglycosides possess natural defensive structural elements that can circumvent drug resistance mechanisms. Thus, a detailed understanding of aminoglycoside biosynthesis will enable us to apply Nature's biosynthetic strategy towards expanding structural diversity in order to produce novel and more robust aminoglycoside analogs. The engineered biosynthesis of novel aminoglycosides is required not only to develop effective therapeutics against the emerging `superbugs' but also to reinvigorate antibiotic lead discovery in readiness for the emerging post-antibiotic era. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CURRENT BIOLOGY LTD | - |
dc.subject | ACID SIDE-CHAIN | - |
dc.subject | GENTAMICIN BIOSYNTHESIS | - |
dc.subject | MODIFYING ENZYMES | - |
dc.subject | BRANCH POINT | - |
dc.subject | LAST STEP | - |
dc.subject | ANTIBIOTICS | - |
dc.subject | DISCOVERY | - |
dc.subject | GENE | - |
dc.subject | BUTIROSIN | - |
dc.subject | KANAMYCIN | - |
dc.title | Biosynthetic pathways of aminoglycosides and their engineering | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Je Won | - |
dc.identifier.doi | 10.1016/j.copbio.2017.03.019 | - |
dc.identifier.scopusid | 2-s2.0-85016425152 | - |
dc.identifier.wosid | 000418313200007 | - |
dc.identifier.bibliographicCitation | CURRENT OPINION IN BIOTECHNOLOGY, v.48, pp.33 - 41 | - |
dc.relation.isPartOf | CURRENT OPINION IN BIOTECHNOLOGY | - |
dc.citation.title | CURRENT OPINION IN BIOTECHNOLOGY | - |
dc.citation.volume | 48 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 41 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | ACID SIDE-CHAIN | - |
dc.subject.keywordPlus | GENTAMICIN BIOSYNTHESIS | - |
dc.subject.keywordPlus | MODIFYING ENZYMES | - |
dc.subject.keywordPlus | BRANCH POINT | - |
dc.subject.keywordPlus | LAST STEP | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | BUTIROSIN | - |
dc.subject.keywordPlus | KANAMYCIN | - |
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