Biosynthetic pathways of aminoglycosides and their engineering
- Authors
- Park, Je Won; Ban, Yeon Hee; Nam, Sang-Jip; Cha, Sun-Shin; Yoon, Yeo Joon
- Issue Date
- 12월-2017
- Publisher
- CURRENT BIOLOGY LTD
- Citation
- CURRENT OPINION IN BIOTECHNOLOGY, v.48, pp.33 - 41
- Indexed
- SCIE
SCOPUS
- Journal Title
- CURRENT OPINION IN BIOTECHNOLOGY
- Volume
- 48
- Start Page
- 33
- End Page
- 41
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81424
- DOI
- 10.1016/j.copbio.2017.03.019
- ISSN
- 0958-1669
- Abstract
- Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics. As Nature's gift, some aminoglycosides possess natural defensive structural elements that can circumvent drug resistance mechanisms. Thus, a detailed understanding of aminoglycoside biosynthesis will enable us to apply Nature's biosynthetic strategy towards expanding structural diversity in order to produce novel and more robust aminoglycoside analogs. The engineered biosynthesis of novel aminoglycosides is required not only to develop effective therapeutics against the emerging `superbugs' but also to reinvigorate antibiotic lead discovery in readiness for the emerging post-antibiotic era.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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