Validation and Application of HPLC-ESI-MS/MS Method for the Determination of Irsogladine
DC Field | Value | Language |
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dc.contributor.author | Hoang, N. H. | - |
dc.contributor.author | Huong, N. L. | - |
dc.contributor.author | Hong, S. -Y. | - |
dc.contributor.author | Park, Je Won | - |
dc.date.accessioned | 2021-09-02T22:49:28Z | - |
dc.date.available | 2021-09-02T22:49:28Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 1233-2356 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81459 | - |
dc.description.abstract | A highly sensitive analytical tool for the fast quantification of irsogladine in human plasma was developed. Cleanup using a solid-phase extraction technique is a simple method for extracting both irsogladine and lamotrigine (internal standard) spiked into human plasma. The resolvable separation of both analytes through reversed-phase high-performance liquid chromatography (HPLC) was carried out within 5 min. The HPLC-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) method, which was operated in a selected reaction monitoring mode specific to the target analytes, was verified for use in the quantification of irsogladine. The inter-and intra-day precision (relative standard deviation, RSD) of irsogladine spiked into quality control samples were <7%, and their accuracies were between 96.6% and 102.1%. The calibration curve for irsogladine spiked into human plasma was linear over the range from 1.8 to 100 ng mL(-1) with lower limit of quantification at 1.8 ng mL(-1). The established method was successfully applied for a bioequivalence study of irsogladine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AKADEMIAI KIADO RT | - |
dc.subject | MALEATE | - |
dc.title | Validation and Application of HPLC-ESI-MS/MS Method for the Determination of Irsogladine | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Je Won | - |
dc.identifier.doi | 10.1556/1326.2017.00024 | - |
dc.identifier.scopusid | 2-s2.0-85090542963 | - |
dc.identifier.wosid | 000416256600004 | - |
dc.identifier.bibliographicCitation | ACTA CHROMATOGRAPHICA, v.29, no.4, pp.459 - 462 | - |
dc.relation.isPartOf | ACTA CHROMATOGRAPHICA | - |
dc.citation.title | ACTA CHROMATOGRAPHICA | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 459 | - |
dc.citation.endPage | 462 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | MALEATE | - |
dc.subject.keywordAuthor | Irsogladine | - |
dc.subject.keywordAuthor | human plasma | - |
dc.subject.keywordAuthor | HPLC-ESI-MS/MS | - |
dc.subject.keywordAuthor | bioequivalence study | - |
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