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Surface immobilization of biphasic calcium phosphate nanoparticles on 3D printed poly(caprolactone) scaffolds enhances osteogenesis and bone tissue regeneration

Authors
Shim, Kyu-SikKim, Sung EunYun, Young-PilJeon, Daniel I.Kim, Hak JunPark, KyeongsoonSong, Hae-Ryong
Issue Date
25-11월-2017
Publisher
ELSEVIER SCIENCE INC
Keywords
Three-dimensional (3D) printed scaffolds; Biphasic calcium phosphate (BCP); MG-63 cells; Tibial defect model; New bone formation
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.55, pp.101 - 109
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume
55
Start Page
101
End Page
109
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81511
DOI
10.1016/j.jiec.2017.06.033
ISSN
1226-086X
Abstract
We fabricated biphasic calcium phosphate nanoparticles (BCP NPs)-immobilized on the surface of 3D printed PCL (BCP-IM-PCL) scaffolds, and evaluated in vitro osteogenesis and in vivo new bone formation in rat tibial defect model. In vitro and in vivo studies showed that BCP-IM-PCL significantly enhanced osteogenic markers (i.e., ALP activity, calcium deposition, and the expression of osteocalcin and osteopontin) and markedly increased new bone formation and mineralized bone tissues in tibial defect area, compared to unmodified PCL and BCP-mixed PCL scaffolds. This study demonstrated that BCP NPs-immobilized on the surface of PCL scaffolds are promising templates for bone tissue regeneration. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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