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Idh2 deficiency accelerates renal dysfunction in aged mice

Authors
Lee, Su JeongCha, HanvitLee, SeoyoonKim, HyunjinKu, Hyeong JunKim, Sung HwanPark, Jung HyunLee, Jin HyupPark, Kwon MooPark, Jeen-Woo
Issue Date
4-11월-2017
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Aging; Antioxidant enzyme; Knockout mice; Redox status; Mitochondria
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.493, no.1, pp.34 - 39
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
493
Number
1
Start Page
34
End Page
39
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81582
DOI
10.1016/j.bbrc.2017.09.082
ISSN
0006-291X
Abstract
The free radical or oxidative stress theory of aging postulates that senescence is due to an accumulation of cellular oxidative damage, caused largely by reactive oxygen species (ROS) that are produced as byproducts of normal metabolic processes in mitochondria. The oxidative stress may arise as a result of either increased ROS production or decreased ability to detoxify ROS. The availability of the mitochondrial NADPH pool is critical for the maintenance of the mitochondrial antioxidant system. The major enzyme responsible for generating mitochondrial NADPH is mitochondrial NADP-dependent isocitrate dehydrogenase (IDH2). Depletion of IDH2 in mice (idh2(-/-)) shortens life span and accelerates the degeneration of multiple age-sensitive traits, such as hair grayness, skin pathology, and eye pathology. Among the various internal organs tested in this study, IDH2 depletion-induced acceleration of senescence was uniquely observed in the kidney. Renal function and structure were greatly deteriorated in 24 month-old idh2(+) mice compared with wild-type. In addition, disruption of redox status, which promotes oxidative damage and apoptosis, was more pronounced in idh2(+) mice. These data support a significant role for increased oxidative stress as a result of compromised mitochondrial antioxidant defenses in modulating life span in mice, and thus support the oxidative stress theory of aging. (C) 2017 Elsevier Inc. All rights reserved.
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