Change in Weight and Body Mass Index Associated With All- Cause Mortality in Korea: A Nationwide Longitudinal Study
- Authors
- Kim, Yang-Hyun; Kim, Seon Mee; Han, Kyung-do; Son, Jang-Won; Lee, Seong-Su; Oh, Sang Woo; Lee, Won-Young; Yoo, Soon Jib
- Issue Date
- 1-11월-2017
- Publisher
- ENDOCRINE SOC
- Citation
- JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.102, no.11, pp.4041 - 4050
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Volume
- 102
- Number
- 11
- Start Page
- 4041
- End Page
- 4050
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81603
- DOI
- 10.1210/jc.2017-00787
- ISSN
- 0021-972X
- Abstract
- Context: Many studies have reported conflicting evidence on the association between weight change and mortality. Objective: We investigated the association between weight change and subsequent all-cause mortality, using a large-scale, population-based cohort from the National Health Insurance System health checkup data between 2005 and 2015. Methods: A total of 11,524,763 subjects older than age 20 years were included. Weight was measured every 2 years and weight change over 4 years was divided into eight categories, from weight loss >= 15% to weight gain >= 20%, for every 5% of weight change. The hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality were analyzed using multivariable Cox proportional hazard models compared with the stable weight group (weight change >5%) after adjusting for age, sex, smoking, drinking, exercise, diabetes mellitus, hypertension, dyslipidemia, cancer, and income. Results: Weight loss was associated with increased mortality rates compared with weight gain; the group with weight loss >= 15% had the highest HR for all-cause mortality (HR, 2.598; 95% CI, 2.537 to 2.659). The HR for all-cause mortality in the >= 20% weight gain group was 1.784 (95% CI, 1.695 to 1.877). Across all body mass index (BMI) categories, weight loss >= 15% was associated with increased mortality rates and the highest mortality rates were found in the BMI >= 30 kg/m(2) group (HR, 3.469; 95% CI, 2.236 to 5.381). Conclusions: Weight change over 4 years showed a reverse J-shaped all-cause mortality curve, independent of BMI status. Weight loss was associated with a greater risk of mortality than was weight gain.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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