Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea
DC Field | Value | Language |
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dc.contributor.author | Seok, Jin Myoung | - |
dc.contributor.author | Cho, Hye-Jin | - |
dc.contributor.author | Ahn, Suk-Won | - |
dc.contributor.author | Cho, Eun Bin | - |
dc.contributor.author | Park, Min Su | - |
dc.contributor.author | Joo, In-Soo | - |
dc.contributor.author | Shin, Ha Young | - |
dc.contributor.author | Kim, Sun-Young | - |
dc.contributor.author | Kim, Byung-Jo | - |
dc.contributor.author | Kim, Jong Kuk | - |
dc.contributor.author | Cho, Joong-Yang | - |
dc.contributor.author | Huh, So-Young | - |
dc.contributor.author | Kwon, Ohyun | - |
dc.contributor.author | Lee, Kwang-Ho | - |
dc.contributor.author | Kim, Byoung Joon | - |
dc.contributor.author | Min, Ju-Hong | - |
dc.date.accessioned | 2021-09-02T23:48:32Z | - |
dc.date.available | 2021-09-02T23:48:32Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1352-4585 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81751 | - |
dc.description.abstract | Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (. 50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (< 50 years of age at onset). Clinical, laboratory, and magnetic resonance imaging (MRI) parameters were investigated. Results: Among a total of 147 patients (125 female; age of onset, 39.4 +/- 15.2 years), 45 patients (30.6%) had an age of onset of more than 50 years. Compared to patients with EO-NMOSD, patients with LONMOSD had more frequent isolated spinal cord involvement at onset (64.4% vs 37.2%, p = 0.002), less frequent involvement of the optic nerve (40.0% vs 67.7%, p = 0.002), and less frequent brain MRI lesions (31.1% vs 50.0%, p = 0.034). Furthermore, there was a significant positive correlation between age of onset and Expanded Disability Status Scale (EDSS) score at last follow-up (r = 0.246, p = 0.003). Conclusion: Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | REMITTING MULTIPLE-SCLEROSIS | - |
dc.subject | HIGH-YIELD PROCESS | - |
dc.subject | DISEASE-ACTIVITY | - |
dc.subject | NO EVIDENCE | - |
dc.subject | INTERFERON BETA-1A | - |
dc.subject | CONTROLLED-TRIAL | - |
dc.subject | DACLIZUMAB | - |
dc.subject | MS | - |
dc.subject | NATALIZUMAB | - |
dc.subject | DISABILITY | - |
dc.title | Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Jo | - |
dc.identifier.doi | 10.1177/1352458516685416 | - |
dc.identifier.scopusid | 2-s2.0-85043316274 | - |
dc.identifier.wosid | 000414783200092 | - |
dc.identifier.bibliographicCitation | MULTIPLE SCLEROSIS JOURNAL, v.23, no.13, pp.1748 - 1756 | - |
dc.relation.isPartOf | MULTIPLE SCLEROSIS JOURNAL | - |
dc.citation.title | MULTIPLE SCLEROSIS JOURNAL | - |
dc.citation.volume | 23 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1748 | - |
dc.citation.endPage | 1756 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | REMITTING MULTIPLE-SCLEROSIS | - |
dc.subject.keywordPlus | HIGH-YIELD PROCESS | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | NO EVIDENCE | - |
dc.subject.keywordPlus | INTERFERON BETA-1A | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | DACLIZUMAB | - |
dc.subject.keywordPlus | MS | - |
dc.subject.keywordPlus | NATALIZUMAB | - |
dc.subject.keywordPlus | DISABILITY | - |
dc.subject.keywordAuthor | Neuromyelitis optica (NMO) | - |
dc.subject.keywordAuthor | neuromyelitis optica spectrum disorder (NMOSD) | - |
dc.subject.keywordAuthor | late-onset neuromyelitis optica | - |
dc.subject.keywordAuthor | seropositive neuromyelitis optica spectrum disorder | - |
dc.subject.keywordAuthor | age of onset | - |
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