Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea

Authors
Seok, Jin MyoungCho, Hye-JinAhn, Suk-WonCho, Eun BinPark, Min SuJoo, In-SooShin, Ha YoungKim, Sun-YoungKim, Byung-JoKim, Jong KukCho, Joong-YangHuh, So-YoungKwon, OhyunLee, Kwang-HoKim, Byoung JoonMin, Ju-Hong
Issue Date
11월-2017
Publisher
SAGE PUBLICATIONS LTD
Keywords
Neuromyelitis optica (NMO); neuromyelitis optica spectrum disorder (NMOSD); late-onset neuromyelitis optica; seropositive neuromyelitis optica spectrum disorder; age of onset
Citation
MULTIPLE SCLEROSIS JOURNAL, v.23, no.13, pp.1748 - 1756
Indexed
SCIE
SCOPUS
Journal Title
MULTIPLE SCLEROSIS JOURNAL
Volume
23
Number
13
Start Page
1748
End Page
1756
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81751
DOI
10.1177/1352458516685416
ISSN
1352-4585
Abstract
Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (. 50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (< 50 years of age at onset). Clinical, laboratory, and magnetic resonance imaging (MRI) parameters were investigated. Results: Among a total of 147 patients (125 female; age of onset, 39.4 +/- 15.2 years), 45 patients (30.6%) had an age of onset of more than 50 years. Compared to patients with EO-NMOSD, patients with LONMOSD had more frequent isolated spinal cord involvement at onset (64.4% vs 37.2%, p = 0.002), less frequent involvement of the optic nerve (40.0% vs 67.7%, p = 0.002), and less frequent brain MRI lesions (31.1% vs 50.0%, p = 0.034). Furthermore, there was a significant positive correlation between age of onset and Expanded Disability Status Scale (EDSS) score at last follow-up (r = 0.246, p = 0.003). Conclusion: Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Byung Jo photo

Kim, Byung Jo
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE