Anti-inflammatory effect of glucose-lysine Maillard reaction products on intestinal inflammation model in vivo
- Authors
- Hong, Chung-Oui; Rhee, Chae Hong; Pyo, Min Cheol; Lee, Kwang-Won
- Issue Date
- 11월-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Inflammatory bowel diseases; Dextran sulfate sodium; Colitis; Maillard reaction products; Cytokines
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.52, pp.324 - 332
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 52
- Start Page
- 324
- End Page
- 332
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81796
- DOI
- 10.1016/j.intimp.2017.09.009
- ISSN
- 1567-5769
- Abstract
- Inflammatory bowel diseases (IBDs) are chronic disorders that are characterized by intestinal epithelial inflammation and injury. Currently, the most employed therapies are antibiotics and anti-inflammatory drugs; however, the side effects limit long-term effectiveness. We evaluated the impact of glucose-lysine Maillard reaction products (Glc-Lys MRPs) on colitis, induced in rats by an administration of 5% dextran sulfate sodium (DSS) in drinking water. Glc-Lys MRPs ameliorate DSS-induced colitis, as determined by a decrease in disease index activity, colon weight/length ratio, nitric oxide levels in serum, recovery of body weight loss, colon length and serum lysozyme levels. Furthermore, Glc-Lys MRPs increase the glutathione content and the activity of glutathione peroxidase, superoxide dismutase and catalase, and inhibit lipid peroxidation and myeloperoxidase activity in colon tissues. In particular, Glc-Lys MRPs suppress the mRNA level of the inflammatory cytokines and nuclear factor-kappa B in colon tissues. This study suggests the potential of Glc-Lys MRPs in preventing or treating IBDs.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.