Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Oncologic Outcomes and Predictive Factors for Recurrence Following Robot-Assisted Radical Cystectomy for Urothelial Carcinoma: Multicenter Study from Korea

Authors
Shim, Ji SungKwon, Tae GyunRha, Koon HoLee, Young GooLee, Ji YoulJeong, Byong ChangKim, Jae YoonPyun, Jong HyunKang, Sung GuKang, Seok Ho
Issue Date
10월-2017
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Bladder Cancer; Outcomes; Recurrence; Radical Cystectomy; Urothelial Carcinoma
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.10, pp.1662 - 1668
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
32
Number
10
Start Page
1662
End Page
1668
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81983
DOI
10.3346/jkms.2017.32.10.1662
ISSN
1011-8934
Abstract
The aim of our study was to evaluate intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns in a multicenter series of patients treated with robot-assisted radical cystectomy (RARC) for urothelial carcinoma (UC) of the bladder. Between 2007 and 2015, 346 patients underwent RARC at multiple tertiary referral centers in Korea. Descriptive statistics were used for demographics and perioperative variables. Survival and recurrence were estimated with Kaplan-Meier analysis. Logistic regression models were used to determine predictors of recurrence. Median follow-up was 33 months (interquartile range [IQR], 7-50). The numbers of patients with organ-confined and lymph node (LN)-positive disease were 237 (68.4%) and 68 (19.7%), respectively. LN density (120 vs. > 20) was 13.6% and 6.1%, with a median of 17 nodes removed (IQR, 9-23). In logistic regression analysis, type of LN dissection, and pathologic tumor stage were significant predictors of cancer recurrence and death from cancer. Local, distal recurrence and secondary UC occurred in 7 (2.0%), 53 (15.3%), and 4 (1.2%) patients, respectively. The 5-year overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were 78%, 84%, and 73%, respectively. At last follow-up, RFS for extended pelvic LN dissection vs. standard pelvic LN dissection was 70% and 47% (P = 0.038). In addition, at last follow-up, LN density (0 vs. 1-20 vs. over 20) was 67%, 41%, and 29%, respectively (P < 0.001). Patients undergoing RARC in this multi-institutional cohort demonstrated intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns that were not unusual.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kang, Seok Ho photo

Kang, Seok Ho
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE