Novel Self-Assembly-Induced Gelation for Nanofibrous Collagen/Hydroxyapatite Composite Microspheres
DC Field | Value | Language |
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dc.contributor.author | Choi, Jae-Won | - |
dc.contributor.author | Kim, Jong-Woo | - |
dc.contributor.author | Jo, In-Hwan | - |
dc.contributor.author | Koh, Young-Hag | - |
dc.contributor.author | Kim, Hyoun-Ee | - |
dc.date.accessioned | 2021-09-03T00:49:39Z | - |
dc.date.available | 2021-09-03T00:49:39Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1996-1944 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82068 | - |
dc.description.abstract | This study demonstrates the utility of the newly developed self-assembly-induced gelation technique for the synthesis of porous collagen/hydroxyapatite (HA) composite microspheres with a nanofibrous structure. This new approach can produce microspheres of a uniform size using the droplets that form at the nozzle tip before gelation. These microspheres can have a highly nanofibrous structure due to the immersion of the droplets in a coagulation bath (water/acetone), in which the collagen aggregates in the solution can self-assemble into fibrils due to pH-dependent precipitation. Bioactive HA particles were incorporated into the collagen solutions, in order to enhance the bioactivity of the composite microspheres. The composite microspheres exhibited a well-defined spherical morphology and a uniform size for all levels of HA content (0 wt %, 10 wt %, 15 wt %, and 20 wt %). Collagen nanofibersseveral tens of nanometers in sizewere uniformly present throughout the microspheres and the HA particles were also well dispersed. The in vitro apatite-forming ability, assessed using the simulated body fluid (SBF) solution, increased significantly with the incorporation of HA into the composite microspheres. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.subject | INDUCED PHASE-SEPARATION | - |
dc.subject | COLLAGEN MICROSPHERES | - |
dc.subject | TISSUE REGENERATION | - |
dc.subject | BONE | - |
dc.subject | MATRIX | - |
dc.subject | BIOMATERIALS | - |
dc.subject | FABRICATION | - |
dc.subject | DELIVERY | - |
dc.subject | PROTEIN | - |
dc.subject | APATITE | - |
dc.title | Novel Self-Assembly-Induced Gelation for Nanofibrous Collagen/Hydroxyapatite Composite Microspheres | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Young-Hag | - |
dc.identifier.doi | 10.3390/ma10101110 | - |
dc.identifier.scopusid | 2-s2.0-85029784979 | - |
dc.identifier.wosid | 000414639000005 | - |
dc.identifier.bibliographicCitation | MATERIALS, v.10, no.10 | - |
dc.relation.isPartOf | MATERIALS | - |
dc.citation.title | MATERIALS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Metallurgy & Metallurgical Engineering | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Metallurgy & Metallurgical Engineering | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | INDUCED PHASE-SEPARATION | - |
dc.subject.keywordPlus | COLLAGEN MICROSPHERES | - |
dc.subject.keywordPlus | TISSUE REGENERATION | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | APATITE | - |
dc.subject.keywordAuthor | biomaterials | - |
dc.subject.keywordAuthor | porous scaffolds | - |
dc.subject.keywordAuthor | collagen | - |
dc.subject.keywordAuthor | hydroxyapatite | - |
dc.subject.keywordAuthor | in vitro bioactivity | - |
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