Novel Self-Assembly-Induced Gelation for Nanofibrous Collagen/Hydroxyapatite Composite Microspheres
- Authors
- Choi, Jae-Won; Kim, Jong-Woo; Jo, In-Hwan; Koh, Young-Hag; Kim, Hyoun-Ee
- Issue Date
- 10월-2017
- Publisher
- MDPI AG
- Keywords
- biomaterials; porous scaffolds; collagen; hydroxyapatite; in vitro bioactivity
- Citation
- MATERIALS, v.10, no.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- MATERIALS
- Volume
- 10
- Number
- 10
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82068
- DOI
- 10.3390/ma10101110
- ISSN
- 1996-1944
- Abstract
- This study demonstrates the utility of the newly developed self-assembly-induced gelation technique for the synthesis of porous collagen/hydroxyapatite (HA) composite microspheres with a nanofibrous structure. This new approach can produce microspheres of a uniform size using the droplets that form at the nozzle tip before gelation. These microspheres can have a highly nanofibrous structure due to the immersion of the droplets in a coagulation bath (water/acetone), in which the collagen aggregates in the solution can self-assemble into fibrils due to pH-dependent precipitation. Bioactive HA particles were incorporated into the collagen solutions, in order to enhance the bioactivity of the composite microspheres. The composite microspheres exhibited a well-defined spherical morphology and a uniform size for all levels of HA content (0 wt %, 10 wt %, 15 wt %, and 20 wt %). Collagen nanofibersseveral tens of nanometers in sizewere uniformly present throughout the microspheres and the HA particles were also well dispersed. The in vitro apatite-forming ability, assessed using the simulated body fluid (SBF) solution, increased significantly with the incorporation of HA into the composite microspheres.
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Collections - Graduate School > Department of Bioengineering > 1. Journal Articles
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