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Hydrolysate Preparation with High Content of 5-Hydroxytryptophan from Liquid Egg Protein and Its Sleep-Potentiating Activity

Authors
Kwon, Jung IlPark, YooheonHan, Sung HeeSuh, Hyung Joo
Issue Date
10월-2017
Publisher
KOREAN SOC FOOD SCIENCE ANIMAL RESOURCES
Keywords
5-hydroxytryptophan; liquid egg white; alcalase; hydrolysate; sleep-potentiating activity
Citation
KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES, v.37, no.5, pp.646 - 653
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES
Volume
37
Number
5
Start Page
646
End Page
653
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/82140
DOI
10.5851/kosfa.2017.37.5.646
ISSN
1225-8563
Abstract
Alcalase hydrolysis of liquid egg white was used to produce 5-hydroxytryptophan (HT?) under various conditions and investigate the sleep-potentiating activity of liquid egg white hydrolysate (LEH) on pentobarbital-induced sleep. Alcalase hydrolysis yielded the highest content of 5-HTP (13.50 mu g/mL), while neutrase hydrolysis showed the lowest 5-HIT content (5.23 mu g/mL). The liquid egg white to water ratio (1:1) was optimal for the production of 5-HTP with high amino-nitrogen (A-N) content and degree of hydrolysis. The 5-HIT, amino nitrogen, and degree of hydrolysis increased until 24 h of hydrolysis and slightly increased thereafter during hydrolysis with 2% and 5% enzyme addition. 5-HIT administration at doses of 6 and 9 mg/kg significantly increased sleep duration and decreased sleep latency time compared to that in the control (p<0.05). LEH (150 mg/mouse), which was equivalent to 5-HIT at 6 mg/kg, significantly decreased sleep latency time and increased sleep duration time compared to that in the control (p<0.05). Oral administration of LEH showed sleep-potentiating effects because of 5-HTP. The sleep-potentiating activity of LEH may have occurred through 5-HTP in our pentobarbital-induced sleep model. LEH may be a valuable alternative to sleep enhancement and may be used as a sleep-potentiating agent.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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