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Stereoselective Synthesis of Anti-Hepatitis B Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage

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dc.contributor.authorHyun, Young Eum-
dc.contributor.authorKim, Hong-Rae-
dc.contributor.authorChoi, Yongseok-
dc.contributor.authorJeong, Lak Shin-
dc.date.accessioned2021-09-03T02:43:32Z-
dc.date.available2021-09-03T02:43:32Z-
dc.date.created2021-06-16-
dc.date.issued2017-09-
dc.identifier.issn2193-5807-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/82499-
dc.description.abstractA stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and Ti-III-mediated regio- and stereoselective epoxide cleavage as key steps.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectVIRUS INFECTION-
dc.subjectASYMMETRIC EPOXIDATION-
dc.subjectVERSATILE INTERMEDIATE-
dc.subject2,3-EPOXY ALCOHOLS-
dc.subjectBMS-200475-
dc.subjectMECHANISM-
dc.subjectKETONES-
dc.subjectPOTENT-
dc.titleStereoselective Synthesis of Anti-Hepatitis B Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage-
dc.typeArticle-
dc.contributor.affiliatedAuthorChoi, Yongseok-
dc.identifier.doi10.1002/ajoc.201700032-
dc.identifier.scopusid2-s2.0-85013771545-
dc.identifier.wosid000410778400012-
dc.identifier.bibliographicCitationASIAN JOURNAL OF ORGANIC CHEMISTRY, v.6, no.9, pp.1213 - 1218-
dc.relation.isPartOfASIAN JOURNAL OF ORGANIC CHEMISTRY-
dc.citation.titleASIAN JOURNAL OF ORGANIC CHEMISTRY-
dc.citation.volume6-
dc.citation.number9-
dc.citation.startPage1213-
dc.citation.endPage1218-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusVERSATILE INTERMEDIATE-
dc.subject.keywordPlus2,3-EPOXY ALCOHOLS-
dc.subject.keywordPlusBMS-200475-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusKETONES-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusVIRUS INFECTION-
dc.subject.keywordPlusASYMMETRIC EPOXIDATION-
dc.subject.keywordAuthorcarbocyclic nucleoside-
dc.subject.keywordAuthorentecavir-
dc.subject.keywordAuthorhepatitis B-
dc.subject.keywordAuthorStereoselective synthesis-
dc.subject.keywordAuthortitanium-
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