Stereoselective Synthesis of Anti-Hepatitis B Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage
- Authors
- Hyun, Young Eum; Kim, Hong-Rae; Choi, Yongseok; Jeong, Lak Shin
- Issue Date
- 9월-2017
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- carbocyclic nucleoside; entecavir; hepatitis B; Stereoselective synthesis; titanium
- Citation
- ASIAN JOURNAL OF ORGANIC CHEMISTRY, v.6, no.9, pp.1213 - 1218
- Indexed
- SCIE
SCOPUS
- Journal Title
- ASIAN JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 6
- Number
- 9
- Start Page
- 1213
- End Page
- 1218
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82499
- DOI
- 10.1002/ajoc.201700032
- ISSN
- 2193-5807
- Abstract
- A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and Ti-III-mediated regio- and stereoselective epoxide cleavage as key steps.
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