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Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of alpha-MSH-stimulated melanogenesis
- Authors
- Jo, Hyeju; Choi, Minho; Sim, Jaeuk; Viji, Mayavan; Li, Siyuan; Lee, Young Hee; Kim, Youngsoo; Seo, Seung-Yong; Zhou, Yuanyuan; Lee, Kiho; Kim, Wun-Jae; Hong, Jin Tae; Lee, Heesoon; Jung, Jae-Kyung
- Issue Date
- 1-8월-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Caffeic acid; Melanogenesis; alpha-MSH; Caffeamide; Skin whitening
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.15, pp.3374 - 3377
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 27
- Number
- 15
- Start Page
- 3374
- End Page
- 3377
- ISSN
- 0960-894X
- Abstract
- We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of alpha-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities. (C) 2017 Elsevier Ltd. All rights reserved.
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