Expression and prognostic significance of programmed death protein 1 and programmed death ligand-1, and cytotoxic T lymphocyte-associated molecule-4 in hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Chang, Hyeyoon | - |
dc.contributor.author | Jung, Wonkyung | - |
dc.contributor.author | Kim, Aeree | - |
dc.contributor.author | Kim, Han Kyeom | - |
dc.contributor.author | Kim, Wan Bae | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Kim, Baek-Hui | - |
dc.date.accessioned | 2021-09-03T03:10:23Z | - |
dc.date.available | 2021-09-03T03:10:23Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 0903-4641 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82611 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is one of the most common malignancies and causes of death worldwide. In this study, we assessed the correlation between clinicopathologic factors with programmed cell death protein 1 (PD-1) and programmed cell death ligand-1 (PD-L1), and cytotoxic T lymphocyte-associated molecule-4 (CTLA-4) expressions. Furthermore, we analyzed the prognostic significance of these proteins in a subgroup of patients. We retrospectively evaluated the PD-1, PD-L1, and CTLA-4 expressions in 294 HCC tissue microarray samples using immunohistochemistry. PD-1 and PD-L1 expressions were significant related to high CD8+ tumor-infiltrating lymphocytes (TILs) (r = 0.664, p < 0.001 and r = 0.149, p = 0.012). Only high Edmondson-Steiner grade was statistically related to high PD-1 expression. High PD-L1 expression was demonstrated as an independent poor prognostic factor for disease-free survival in addition to previous known factors, size >5 cm and serum albumin <= 3.5 g/dL in high CD8+ TILs group. We have demonstrated that the combined high expression of PD-L1 and CD8+ TIL is an important prognostic factor related to the immune checkpoint pathway in HCC and furthermore, there is a possibility that it could be used as a predictor of therapeutic response. Also, this result would be helpful in evaluating the applicable group of PD-1/PD-L1 blocking agent for HCC patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | RENAL-CELL CARCINOMA | - |
dc.subject | POOR-PROGNOSIS | - |
dc.subject | PD-L1 EXPRESSION | - |
dc.subject | OVARIAN-CANCER | - |
dc.subject | HEPATITIS-B | - |
dc.subject | APOPTOSIS | - |
dc.subject | CTLA-4 | - |
dc.title | Expression and prognostic significance of programmed death protein 1 and programmed death ligand-1, and cytotoxic T lymphocyte-associated molecule-4 in hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Aeree | - |
dc.contributor.affiliatedAuthor | Kim, Han Kyeom | - |
dc.contributor.affiliatedAuthor | Kim, Wan Bae | - |
dc.contributor.affiliatedAuthor | Kim, Baek-Hui | - |
dc.identifier.doi | 10.1111/apm.12703 | - |
dc.identifier.scopusid | 2-s2.0-85019148994 | - |
dc.identifier.wosid | 000405800700002 | - |
dc.identifier.bibliographicCitation | APMIS, v.125, no.8, pp.690 - 698 | - |
dc.relation.isPartOf | APMIS | - |
dc.citation.title | APMIS | - |
dc.citation.volume | 125 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 690 | - |
dc.citation.endPage | 698 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | RENAL-CELL CARCINOMA | - |
dc.subject.keywordPlus | POOR-PROGNOSIS | - |
dc.subject.keywordPlus | PD-L1 EXPRESSION | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | HEPATITIS-B | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CTLA-4 | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | programmed cell death protein 1 | - |
dc.subject.keywordAuthor | programmed cell death ligand-1 | - |
dc.subject.keywordAuthor | cytotoxic T lymphocyte-associated molecule-4 | - |
dc.subject.keywordAuthor | tumor-infiltrating lymphocytes | - |
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