Expression and prognostic significance of programmed death protein 1 and programmed death ligand-1, and cytotoxic T lymphocyte-associated molecule-4 in hepatocellular carcinoma
- Authors
- Chang, Hyeyoon; Jung, Wonkyung; Kim, Aeree; Kim, Han Kyeom; Kim, Wan Bae; Kim, Ji Hoon; Kim, Baek-Hui
- Issue Date
- 8월-2017
- Publisher
- WILEY
- Keywords
- Hepatocellular carcinoma; programmed cell death protein 1; programmed cell death ligand-1; cytotoxic T lymphocyte-associated molecule-4; tumor-infiltrating lymphocytes
- Citation
- APMIS, v.125, no.8, pp.690 - 698
- Indexed
- SCIE
SCOPUS
- Journal Title
- APMIS
- Volume
- 125
- Number
- 8
- Start Page
- 690
- End Page
- 698
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82611
- DOI
- 10.1111/apm.12703
- ISSN
- 0903-4641
- Abstract
- Hepatocellular carcinoma (HCC) is one of the most common malignancies and causes of death worldwide. In this study, we assessed the correlation between clinicopathologic factors with programmed cell death protein 1 (PD-1) and programmed cell death ligand-1 (PD-L1), and cytotoxic T lymphocyte-associated molecule-4 (CTLA-4) expressions. Furthermore, we analyzed the prognostic significance of these proteins in a subgroup of patients. We retrospectively evaluated the PD-1, PD-L1, and CTLA-4 expressions in 294 HCC tissue microarray samples using immunohistochemistry. PD-1 and PD-L1 expressions were significant related to high CD8+ tumor-infiltrating lymphocytes (TILs) (r = 0.664, p < 0.001 and r = 0.149, p = 0.012). Only high Edmondson-Steiner grade was statistically related to high PD-1 expression. High PD-L1 expression was demonstrated as an independent poor prognostic factor for disease-free survival in addition to previous known factors, size >5 cm and serum albumin <= 3.5 g/dL in high CD8+ TILs group. We have demonstrated that the combined high expression of PD-L1 and CD8+ TIL is an important prognostic factor related to the immune checkpoint pathway in HCC and furthermore, there is a possibility that it could be used as a predictor of therapeutic response. Also, this result would be helpful in evaluating the applicable group of PD-1/PD-L1 blocking agent for HCC patients.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.