Determinants of Long-Term Durable Glycemic Control in New-Onset Type 2 Diabetes Mellitus
- Authors
- Kim, Kyoung Jin; Choi, Ju Hee; Kim, Kyeong Jin; An, Jee Hyun; Kim, Hee Young; Kim, Sin Gon; Kim, Nam Hoon
- Issue Date
- 8월-2017
- Publisher
- KOREAN DIABETES ASSOC
- Keywords
- Diabetes mellitus; type 2; Durability; Glycemic control
- Citation
- DIABETES & METABOLISM JOURNAL, v.41, no.4, pp.284 - 295
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- DIABETES & METABOLISM JOURNAL
- Volume
- 41
- Number
- 4
- Start Page
- 284
- End Page
- 295
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82630
- DOI
- 10.4093/dmj.2017.41.4.284
- ISSN
- 2233-6079
- Abstract
- Background: Long-term durable glycemic control is a difficult goal in the management of type 2 diabetes mellitus (T2DM). We evaluated the factors associated with durable glycemic control in a real clinical setting. Methods: We retrospectively reviewed the medical records of 194 new-onset, drug-naive patients with T2DM who were diagnosed between January 2011 and March 2013, and were followed up for > 2 years. Glycemic durability was defined as the maintenance of optimal glycemic control (glycosylated hemoglobin [HbA1c] <7.0%) for 2 years without substitution or adding other glucose-lowering agents. Clinical factors and glycemic markers associated with glycemic durability were compared between two groups: a durability group and a non-durability group. Results: Patients in the durability group had a higher baseline body mass index (26.1 kg/m(2) vs. 24.9 kg/m(2)) and lower HbA1c (8.6% vs. 9.7%) than the non-durability group. The initial choice of glucose-lowering agents was similar in both groups, except for insulin and sulfonylureas, which were more frequently prescribed in the non-durability group. In multiple logistic regression analyses, higher levels of education, physical activity, and homeostasis model assessment of beta-cell function (HOMA-beta) were associated with glycemic durability. Notably, lower HbA1c (<7.0%) at baseline and first follow-up were significantly associated with glycemic durability (adjusted odds ratio [OR], 7.48; 95% confidence interval [CI], 2.51 to 22.3) (adjusted OR, 9.27; 95% CI, 1.62 to 53.1, respectively), after adjusting for confounding variables including the types of glucose-lowering agents. Conclusion: Early achievement of HbA1c level within the glycemic target was a determinant of long-term glycemic durability in new-onset T2DM, as were higher levels of education, physical activity, and HOMA-beta.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.