eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation
- Authors
- Min, Kyung-Won; Davila, Sylvia; Zealy, Richard W.; Lloyd, Lawson T.; Lee, In Young; Lee, Rumi; Roh, Kyung Hye; Jung, Ahjin; Jemielity, Jacek; Choi, Eui-Ju; Chang, Jeong Ho; Yoon, Je-Hyun
- Issue Date
- Jul-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- eIF4E phosphorylation; MST1; Post-transcriptional modification; Long noncoding RNA; Translation
- Citation
- BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, v.1860, no.7, pp.761 - 772
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
- Volume
- 1860
- Number
- 7
- Start Page
- 761
- End Page
- 772
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82951
- DOI
- 10.1016/j.bbagrm.2017.05.002
- ISSN
- 1874-9399
- Abstract
- Post-transcriptional gene regulation is an important step in eukaryotic gene expression. The last step to govern production of nascent peptides is during the process of mRNA translation. mRNA translation is controlled by many translation initiation factors that are susceptible to post-translational modifications. Here we report that one of the translation initiation factors, eIF4E, is phosphorylated by Mammalian Ste20-like kinase (MST1). Upon phosphorylation, eIF4E weakly interacts with the 5' CAP to inhibit mRNA translation. Simultaneously, active polyribosome is more associated with long noncoding RNAs (lncRNAs). Moreover, the linc00689-derived micropeptide, STORM ((S) under bar tress-and (T) under bar NF-alpha-activated (O) under bar RF (M) under bar icropeptide), is triggered by TNF-alpha-induced and MST1-mediated eIF4E phosphorylation, which exhibits molecular mimicry of SRP19 and, thus, competes for 7SL RNA. Our findings have uncovered a novel function of MST1 in mRNA and lncRNA translation by direct phosphorylation of eIF4E. This novel signaling pathway will provide new platforms for regulation of mRNA translation via post-translational protein modification.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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