Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications
DC Field | Value | Language |
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dc.contributor.author | Shin, Junghoon | - |
dc.contributor.author | Koh, Youngil | - |
dc.contributor.author | Youk, Jeonghwan | - |
dc.contributor.author | Kim, Miso | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Choi, Chul Won | - |
dc.contributor.author | Sung, Hwa Jung | - |
dc.contributor.author | Park, Yong | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Kim, Inho | - |
dc.date.accessioned | 2021-09-03T04:42:36Z | - |
dc.date.available | 2021-09-03T04:42:36Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83048 | - |
dc.description.abstract | Background/Aims: Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population. Methods: We reviewed the medical records of MM patients whose age was 40 years or younger at diagnosis. Results: A total of 32 patients were analyzed (male to female ratio 19: 13, median age 37 years). According to International Staging System, 29%, 48%, and 16% were in stage I, II, and III, respectively. Light chain myeloma accounted for 30%. Clinically significant anemia, hypercalcemia, azotemia, and hypoalbuminemia were present in 29%, 28%, 13%, and 28%, respectively. Three or more lytic bone lesions were detected in 45% of the patients, whereas 13% had no lytic bone lesions. Regarding treatment, 79% of patients received autologous hematopoietic stem cell transplantation. After a median follow-up duration of 64 months, the 1-, 3-, and 5-year overall survival (OS) rates were 84%, 62%, and 54%, respectively. The median OS was 61 months for the entire cohort. Conclusions: In our study, MM patients aged 40 years or younger at diagnosis showed no superior survival compared to those of the moderately elderly patients based on historical data. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.subject | PROGNOSTIC-FACTOR | - |
dc.subject | AGE | - |
dc.subject | SURVIVAL | - |
dc.subject | FEATURES | - |
dc.title | Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Byung Soo | - |
dc.contributor.affiliatedAuthor | Choi, Chul Won | - |
dc.contributor.affiliatedAuthor | Sung, Hwa Jung | - |
dc.contributor.affiliatedAuthor | Park, Yong | - |
dc.identifier.doi | 10.3904/kjim.2016.256 | - |
dc.identifier.scopusid | 2-s2.0-85025129945 | - |
dc.identifier.wosid | 000405512900017 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.32, no.4, pp.722 - 730 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 32 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 722 | - |
dc.citation.endPage | 730 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002240935 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTOR | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordAuthor | Multiple myeloma | - |
dc.subject.keywordAuthor | Young adult | - |
dc.subject.keywordAuthor | Hematopoietic stem cell transplantation | - |
dc.subject.keywordAuthor | Treatment outcome | - |
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