Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications
- Authors
- Shin, Junghoon; Koh, Youngil; Youk, Jeonghwan; Kim, Miso; Kim, Byung Soo; Choi, Chul Won; Sung, Hwa Jung; Park, Yong; Yoon, Sung-Soo; Kim, Inho
- Issue Date
- 7월-2017
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Multiple myeloma; Young adult; Hematopoietic stem cell transplantation; Treatment outcome
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.32, no.4, pp.722 - 730
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 32
- Number
- 4
- Start Page
- 722
- End Page
- 730
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83048
- DOI
- 10.3904/kjim.2016.256
- ISSN
- 1226-3303
- Abstract
- Background/Aims: Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population. Methods: We reviewed the medical records of MM patients whose age was 40 years or younger at diagnosis. Results: A total of 32 patients were analyzed (male to female ratio 19: 13, median age 37 years). According to International Staging System, 29%, 48%, and 16% were in stage I, II, and III, respectively. Light chain myeloma accounted for 30%. Clinically significant anemia, hypercalcemia, azotemia, and hypoalbuminemia were present in 29%, 28%, 13%, and 28%, respectively. Three or more lytic bone lesions were detected in 45% of the patients, whereas 13% had no lytic bone lesions. Regarding treatment, 79% of patients received autologous hematopoietic stem cell transplantation. After a median follow-up duration of 64 months, the 1-, 3-, and 5-year overall survival (OS) rates were 84%, 62%, and 54%, respectively. The median OS was 61 months for the entire cohort. Conclusions: In our study, MM patients aged 40 years or younger at diagnosis showed no superior survival compared to those of the moderately elderly patients based on historical data.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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