Inhibitory effect of bee venom on blood coagulation via anti-serine protease activity
- Authors
- Lee, Jiyun; Park, Jieun; Yeom, Jia; Han, Eun Hye; Lim, Young-Hee
- Issue Date
- 6월-2017
- Publisher
- KOREAN SOC APPLIED ENTOMOLOGY
- Keywords
- Bee venom; Coagulation factor; Thrombin activity; Serine protease
- Citation
- JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, v.20, no.2, pp.599 - 604
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
- Volume
- 20
- Number
- 2
- Start Page
- 599
- End Page
- 604
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83230
- DOI
- 10.1016/j.aspen.2017.03.023
- ISSN
- 1226-8615
- Abstract
- Maintaining a balance between blood flow and hemostasis is very important because both excessive bleeding and excessive coagulation and aggregation can cause death. In this study, the preventive effect of bee venom (BV) on blood coagulation was investigated. BV prolonged coagulation periods in a dose dependent manner compared with the negative control. It did not target any specific coagulation factor(s) but showed a broad spectrum of action against various coagulation factors. BV did not inhibit fibrinolytic activity. BV inhibited trypsin and chymotrypsin activities dose-dependently. In addition, BV did not induce bleeding disorders. In conclusion, BV plays a role in anticoagulation by inhibiting the activities of coagulation factors, which are serine proteases, not via inhibiting thrombin activity. (C) 2017 Korean Society of Applied Entomology, Taiwan Entomological Society and Malaysian Plant Protection
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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