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Microfluidic perfusion bioreactor for optimization of microalgal lipid productivity
- Authors
- Paik, Sang-Min; Sim, Sang-Jun; Jeon, Noo Li
- Issue Date
- Jun-2017
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Microfluidic perfusion bioreactor; Continuous flow; Nutrient gradient; Triacylglycerol; Microalgae
- Citation
- BIORESOURCE TECHNOLOGY, v.233, pp.433 - 437
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIORESOURCE TECHNOLOGY
- Volume
- 233
- Start Page
- 433
- End Page
- 437
- ISSN
- 0960-8524
- Abstract
- Nutrient deprivation in a batch process induces microbes to produce secondary metabolites while drastically constraining cellular growth. A microfluidic continuous perfusion system was designed and tested to culture microalgae, Chlamydomonas reinhardtii, under constant nutrient concentration slightly lower than normal condition. When cultured in 7.5%/7.5% of NH4+/PO42, C. reinhardtii showed a 2.4-fold increase in TAG production with a 3.5-fold increase in biomass compared to level obtained under an only NH4+ depleted condition. The microfluidic continuous perfusion bioreactor with steady continuous nutrient flow can be used to optimize conditions for enhancing secondary metabolite production and increasing microbial biomass. (C) 2017 Elsevier Ltd. All rights reserved.
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Related Researcher
- Sim, Sang Jun
- College of Engineering (Department of Chemical and Biological Engineering)