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2,4-Bis(1,1-dimethylethyl)phenol from Cinnamomum loureirii Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice

Authors
Kim, Cho RongChoi, Soo JungKim, Jae KyeomPark, Chan KyuGim, Min ChulKim, Youn-JungPark, Gwi GunShin, Dong-Hoon
Issue Date
6월-2017
Publisher
PHARMACEUTICAL SOC JAPAN
Keywords
Alzheimer' s disease; acetylcholinesterase inhibitor; Cinnamomum loureirii; 2,4-bis(1,1-dimethylethyl)phenol; cognitive dysfunction; trimethyltin
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.40, no.6, pp.932 - 935
Indexed
SCIE
SCOPUS
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume
40
Number
6
Start Page
932
End Page
935
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/83297
DOI
10.1248/bpb.b16-00997
ISSN
0918-6158
Abstract
We previously reported that the extract of Cinnanzoinum loureirii (C. loureirii) significantly inhibited acetylcholinesterase (AChE), and identified 2,4-bis(1,1-dimethylethyl)phenol (BP) from C. loureirii as a potential AChE inhibitor. The present study, therefore was undertaken to demonstrate the effects of BP from C. loureirii on learning and memory impairment in trimethyltin (TMT)-treated ICR mice. Y-maze and passive avoidance tests were used to test cognitive ability. Further, changes in biochemical parameters in the brain tissue were also assessed in response to TMT injection and BP intervention. BP pre-administration (20, 40 mg/kg/d) in mice significantly protected cognitive dysfunction induced by TMT (p<0.05). Moreover, BP reduced AChE activity and lipid peroxidation but increased acetylcholine levels in the brain. In conclusion, we suggested that BP protected against TMT-induced cognitive dysfunction, and might be a potential agent for alleviating symptoms of neurodegenerative disorders, such as Alzheimer's disease, via modulating cholinergic functions.
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